2. Neurological Disease

Neurological Disease

Neurological Disease

Related Products

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-119221A
    AUY 954 hydrochloride 820240-78-6 98%
    AUY 954 hydrochloride is a potent and selective sphingosine-1-phosphate (S1P(1)) receptor agonist, exhibiting significant immunomodulatory activity. AUY 954 hydrochloride induces a profound and reversible reduction of circulating lymphocytes upon oral administration. AUY 954 hydrochloride has demonstrated efficacy in prolonging cardiac allograft survival when used in combination with RAD001 in a stringent transplantation model. AUY 954 hydrochloride effectively prevents experimental autoimmune neuritis in rats, showcasing its therapeutic potential in autoimmune conditions.
    AUY 954 hydrochloride
  • HY-119223R
    Desmethylmirtazapine (Standard) 61337-68-6
    Desmethylmirtazapine (Standard) is the analytical standard of Desmethylmirtazapine. This product is intended for research and analytical applications. Desmethylmirtazapine is an active metabolite of Mirtazapine that has antidepressant effects.
    Desmethylmirtazapine (Standard)
  • HY-119223S
    Desmethylmirtazapine-d6 hydrochloride
    Desmethylmirtazapine-d6 hydrochloride (Normirtazapine-d6 hydrochloride) is the deuterium labeled Desmethylmirtazapine (HY-119223). Desmethylmirtazapine is an active metabolite of Mirtazapine that has antidepressant effects.
    Desmethylmirtazapine-d6 hydrochloride
  • HY-119413R
    9-Ethyladenine (Standard) 2715-68-6
    Loxoprofen (sodium) (Standard) is the analytical standard of Loxoprofen (sodium). This product is intended for research and analytical applications. Loxoprofen sodium is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen sodium can reduce atherosclerosis and shows antitumor activity.
    9-Ethyladenine (Standard)
  • HY-119419R
    Pirimicarb (Standard) 23103-98-2
    Pirimicarb (Standard) is the analytical standard of Pirimicarb. This product is intended for research and analytical applications. Pirimicarb is a fast-acting selective carbamate insecticide on a wide range of crops including cereals, sugar beet, potatoes, fruits and vegetables. Pirimicarb is an AChE inhibitor and an acaricide.
    Pirimicarb (Standard)
  • HY-119456A
    Romifidine hydrochloride 65896-14-2 98%
    Romifidine hydrochloride is an α2 adrenergic receptor agonist. Romifidine hydrochloride shows sedation effects in vivo.
    Romifidine hydrochloride
  • HY-119696R
    MTIC (Standard) 3413-72-7
    MTIC (Standard) is the analytical standard of MTIC. This product is intended for research and analytical applications. MTIC, the active metabolite of Temozolomide (TMZ), is a DNA alkylating agent. MTIC has antitumor activity [1][2][3][4].
    MTIC (Standard)
  • HY-119810A
    Seletracetam lithium
    Seletracetam (Ucb 44212) lithium, as an analog of the antiepileptic agent Levetiracetam, is a SV2A modulator for the research of epilepsy.
    Seletracetam lithium
  • HY-119810B
    Seletracetam lithium bromide 2024584-38-9 98%
    Seletracetam (Ucb 44212) lithium bromide, an analog of the antiepileptic agent Levetiracetam, is a SV2A modulator for the research of epilepsy.
    Seletracetam lithium bromide
  • HY-119885A
    (±)-Amiflamine 77502-96-6 99.23%
    (±)-Amiflamine (FLA 336) is a potent monoamine oxidase-A (MAO-A) inhibitor with a pIC50 of 5.57.
    (±)-Amiflamine
  • HY-119896R
    Clethodim (Standard) 99129-21-2
    Clethodim (Standard) is the analytical standard of Clethodim. This product is intended for research and analytical applications. Clethodim is a postemergence herbicide. Clethodim shows developmental toxicity and neurotoxicity in zebrafish embryos and larvae.
    Clethodim (Standard)
  • HY-119910A
    Aminoquinol 10023-54-8 98%
    Aminoquinol is a GFRα-1 agonist. Aminoquinol exhibits neurotrophic effects similar to GDNF and induces Ret autophosphorylation in Neuro-2A cells. Aminoquinol can be used in research related to Parkinson's disease.
    Aminoquinol
  • HY-119926A
    13-Hydroxylupanine hydrochloride 6809-89-8 98%
    13-Hydroxylupanine Hydroxylupanine is the typical alkaloid profile of sweet lupins. 13-Hydroxylupanine Hydroxylupanine blocks ganglionic transmission, decreases cardiac contractility and contracts uterine smooth muscle.
    13-Hydroxylupanine hydrochloride
  • HY-119943B
    (R)-PF-06256142 1609583-15-4 99.60%
    (R)-PF-06256142 is the R enantiomer of PF-06256142 with low active. PF-06256142 is a potent and selective orthosteric D1 receptor agonist that can reduce receptor desensitization relative to dopamine and other catechol-containing agonists.
    (R)-PF-06256142
  • HY-119980A
    Fluphenazine dimaleate 3093-66-1 98%
    Fluphenazine dimaleate is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine dimaleate blocks neuronal voltage-gated sodium channels. Fluphenazine dimaleate acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine dimaleate can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine dimaleate can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2.
    Fluphenazine dimaleate
  • HY-119980B
    Fluphenazine hydrochloride 1254-47-3 98%
    Fluphenazine hydrochloride is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine hydrochloride blocks neuronal voltage-gated sodium channels. Fluphenazine hydrochloride acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine hydrochloride can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine hydrochloride can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2.
    Fluphenazine hydrochloride
  • HY-120081B
    Metixene hydrochloride 1553-34-0 98%
    Metixene (Piperidine) hydrochloride hydrate is an anticholinergic and antiparkinsonian agent. Metixene hydrochloride potently inhibits binding of quinuclidinyl benzilate (QNB) with the muscarinic receptor, IC50 and Ki values of 55 nM and 15 nM, respectively. Metixene hydrochloride can be used for the research of parkinsonian.
    Metixene hydrochloride
  • HY-120160A
    Darglitazone Sodium 149904-87-0 98%
    Darglitazone Sodium, a thiazolidinedione, is an orally active, potent, and selective PPAR-γ (peroxisome proliferator-activated receptor) agonist. Darglitazone Sodium is effective in controlling blood glucose and lipid metabolism, and can be used for type II diabetes research.
    Darglitazone Sodium
  • HY-120206B
    Brasofensine sulfate 171655-92-8 98%
    Brasofensine (BMS-204756) sulfate is an oral active dopamine transporter antagonist and can be used for parkinson’s disease research.
    Brasofensine sulfate
  • HY-120782A
    Yhhu-3792 hydrochloride 2624336-93-0 98%
    Yhhu-3792 hydrochloride enhances the self-renewal capability of neural stem cells (NSCs). Yhhu-3792 hydrochloride activates Notch signaling pathway and promotes the expression of Hes3 and Hes5. Yhhu-3792 hydrochloride expands the NSCs pool and promotes endogenous neurogenesis in the hippocampal dentate gyrus (DG) in mouse. Yhhu-3792 hydrochloride increases the spatial and episodic memory abilities of mice. Yhhu-3792 hydrochloride has the potential for the research of impairment of learning and memory associated DG dysfunction.
    Yhhu-3792 hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity